Prof. Dr. med. dent. Matthias Zehnder, PhD
Head, Division of Endodontology
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Clinical Specialisations
Endodontology
Research Interests
My main research interest is to identify new ways to disinfect and fill dental hard tissues. Further interests include molecular markers to improve pulpal and periapical diagnostics and the electrochemical treatment of peri-implantitis.
Selected publications
De-Deus G, Pinho MA, Reis C, Fidel S, Souza E, Zehnder M. NaOCl with reduced surface tension does not improve in situ pulp tissue dissolution. J Endod 39: 1039-43 (2013)
Rechenberg D, Thurnheer T, Zehnder M. Potential systematic error in laboratory experiments on microbial leakage through filled root canals: experimental study. Int Endod J 44: 827-35 (2011)
Mohn D, Zehnder M, Stark WJ, Imfeld T. Electrochemical disinfection of dental implants – a proof of concept. PLoS one 6:e 16157 (2011)
Zehnder M, Wegehaupt F, Attin T. A first study on the usefulness of MMP-9 from dentinal fluid to indicate pulp inflammation. J Endod 37:17-20 (2011)
Mohn D, Bruhin C, Luechinger NA, Stark WJ, Imfeld T, Zehnder M. Composites made of flame-sprayed bioactive glass 45S5 and polymers: bioactivity and immediate sealing properties. Int Endod J 43:1037–1046 (2010)
Waltimo T, Brunner TJ, Vollenweider M, Stark WJ, Zehnder M. Antimicrobial effect of nanometric bioactive glass 45S5. J Dent Res 86, 754-757 (2007)
Links
Publications in ZORA (Zurich Open Repository and Archive)
ZORA Publication List
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Publications
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Continuous Chelation Reduces Instrumentation Time and Straightening of Double-curved Simulated Root Canals in Bovine Dentin. Journal of Endodontics, 51(3):367-372.
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Regulatory issues related to the use of sodium hypochlorite solutions in endodontics. International Endodontic Journal, 58(3):368-378.
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Evaluating the Impact of Ultrasonic Irrigation on Bacterial Levels and Activity Following Chemomechanical Procedures. Journal of Endodontics, 51(2):118-123.
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Solutes in water affect the primary cavitation bubble generated by a pulsed erbium-doped yttrium aluminium garnet laser. Lasers in Medical Science, 39(1):298.
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Compatibility of Dual Rinse 1-Hydroxyethane-1,1-Diphosphonic Acid with Sodium Hypochlorite Solutions Containing Proprietary Additives. Journal of Endodontics, 50(10):1472-1477.
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Impact of final rinse with saline or alcohol solution on root canal sealability. Swiss Dental Journal, 134(4):1-13.
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In vitro and ex vivo comparison of reactive oxygen-releasing granules for internal tooth bleaching. Frontiers in Dental Medicine, 5:1447459.
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Spüllösungen und temporäre Wurzelkanaleinlagen. In: Hülsmann, Michael; Sonntag, David; Arnold, Michael. Das kleine 1x1 der Endodontie. Berlin: QUINTESSENZ Verlag, 1-15.
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Bedarf an Zahnärztinnen und Zahnärzten mitWeiterbildung in Endodontologie lautMitgliedern der Schweizerischen Zahnärztegesellschaft. Swiss Dental Journal, 134(2):161-175.
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4-Year Pulp Survival in a Randomized Trial on Direct Pulp Capping. Journal of Endodontics, 50(1):4-9.
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Precision‐Milled Simulated Curved Root Canals in Bovine Dentine for the Assessment of Chemo‐Mechanical Root Canal Preparation. International Endodontic Journal, 57(1):78-86.
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Assessment of Irrigant Agitation Devices in Simulated Closed and Open Root Canal Systems. Journal of Endodontics, 49(4):438-444.e6.
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The medical device regulation (MDR) from a dental perspective. Frontiers in Dental Medicine, 4:1155820.
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Temporäre Einlagen in der Endodontie : Einfaches klinisches Konzept. Der Freie Zahnarzt, 66(12):70-73.
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The Impact of Changing from First- to Fifth-Generation Nickel-Titanium Rotaries on Root-Filling Quality in a Clinical Undergraduate Course. Swiss Dental Journal, 132(10):684-690.
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MMP-9 Levels and NaOCl Lavage in Randomized Trial on Direct Pulp Capping. Journal of Dental Research, 101(4):414-419.
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Patients with persistent idiopathic dentoalveolar pain in dental practice. International Endodontic Journal, 55(3):231-239.
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A critical analysis of research methods to study clinical molecular biomarkers in Endodontic research. International Endodontic Journal, 55(S1):37-45.
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Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in regenerative endodontics. European Cells and Materials (ECM), 41:233-244.
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Hydrogen Peroxide Versus Sodium Hypochlorite: All a Matter of pH?. Journal of Endodontics, 47(2):297-302.
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Correlation between the clinically diagnosed inflammatory process and periapical index scores in severely painful endodontically involved teeth. International Endodontic Journal, 54(2):172-180.
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Contrast-enhanced micro-CT to assess dental pulp tissue debridement in root canals of extracted teeth: a series of cascading experiments towards method validation. International Endodontic Journal, 54(2):279-293.
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Biofilm im Wurzelkanal. Endodontie, 01:18-27.
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Buffer Solution Reduces Acidic Toothpaste Abrasivity Measured in Standardized Tests. Frontiers in Dental Medicine, 1:612298.
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Effect of dentine cutting efficiency on the lateral force created by torque-controlled rotary instruments. International Endodontic Journal, 53(8):1153-1161.
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What happened to our former students five to six years after graduation? An endodontic teacher's perspective. Swiss Dental Journal, (7-8):584-591.
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New Ways to Disinfect and Fill Dental Hard Tissues. Journal of Clinical Medicine, 9(5):1524.
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Transforming Growth Factor Beta 1 Distribution and Content in the Root Dentin of Young Mature and Immature Human Premolars. Journal of Endodontics, 46(5):641-647.
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Wound Lavage in Studies on Vital Pulp Therapy of Permanent Teeth with Carious Exposures: A Qualitative Systematic Review. Journal of Clinical Medicine, 9(4):984.
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Pulp-derived exosomes in a fibrin-based regenerative root filling material. Journal of Clinical Medicine, 9(2):491.
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Safety assessment of an etidronate in a sodium hypochlorite solution: randomized double‐blind trial. International Endodontic Journal, 52(9):1274-1282.
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Etidronat (Dual Rinse HEDP) zur Wurzelkanalspülung in der klinischen Anwendung. Die Quintessenz, 70(8):896-905.
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Chemical, cytotoxic and genotoxic analysis of etidronate in sodium hypochlorite solution. International Endodontic Journal, 52(8):1228-1234.
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Effects of endodontic irrigants on blood and blood-stained dentin. Heliyon, 5(5):e01794.
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Dentine decalcification and smear layer removal by different ethylenediaminetetraacetic acid and 1-hydroxyethane-1,1-diphosphonic acid species. International Endodontic Journal, 52(2):237-243.
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Biomimetic Conditioning of Human Dentin Using Citric Acid. Journal of Endodontics, 45(1):45-50.
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European Society of Endodontology position statement: Management of deep caries and the exposed pulp. International Endodontic Journal, 52(7):923-934.
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Short-term storage stability of NaOCl solutions when combined with Dual Rinse HEDP. International Endodontic Journal, 51(6):691-696.
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MMP-9 in dentinal fluid correlates with caries lesion depth. Caries Research, 51(5):460-465.
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Interactions between the Tetrasodium Salts of EDTA and 1-Hydroxyethane 1,1-Diphosphonic Acid with Sodium Hypochlorite Irrigants. Journal of Endodontics, 43(4):657-661.
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Effects of endodontic irrigants on biofilm matrix polysaccharides. International Endodontic Journal, 50(2):153-160.
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Iodixanol as a contrast agent in a fibrin hydrogel for endodontic applications. Frontiers in Physiology, 8:152.
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FISHing for gutta-percha-adhered biofilms in purulent post-treatment apical periodontitis. Molecular Oral Microbiology, 32(3):226-235.
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Effects of stem cell factor on cell homing during functional pulp regeneration in human immature teeth. Tissue Engineering. Part A, 23(3-4):115-123.
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Treatment options for permanent teeth with deep caries. Swiss Dental Journal, 126(11):1007-1017.