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Tooth formation, pathology and regeneration using various genetically modified mouse lines in combination with stem cell biology, microfluidics/chips technology and novel live imaging approaches A big variety of model systems related to Notch signaling pathway. A good number of mouse models exhibiting dental anomalies are in process of examination, while the interplay of dental stem cells with nerves and vessels are under investigation in vivo or in vitro (microfluidic devices).
Pagella P, de Vargas Roditi L, Stadlinger B, Moor AE, Mitsiadis TA (2021) A single-cell atlas of human teeth.
iScience. 2021 Apr 23;24(5):102405. doi: 10.1016/j.isci.2021.102405. eCollection 2021 May 21. PMID: 33997688
Claudinot S, Sakabe JI, Oshima H, Gonneau C, Mitsiadis T, Littman D, Bonfanti P, Martens G, Nicolas M, Rochat A, Barrandon Y. (2020) Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.
Nat Commun. 2020 Nov 6;11(1):5645. doi: 10.1038/s41467-020-19485-3. PMID: 33159086
Pagella P, Miran S, Neto E, Martin I, Lamghari M, Mitsiadis TA (2020) Human dental pulp stem cells exhibit enhanced properties in comparison to human bone marrow stem cells on neurites outgrowth.
FASEB J. 2020 Apr;34(4):5499-5511. doi: 10.1096/fj.201902482R. Epub 2020 Feb 25.PMID: 32096581
Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. (2019) A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage.
Nat Cell Biol. 2019 Sep;21(9):1102-1112. doi: 10.1038/s41556-019-0378-2. Epub 2019 Sep 2. PMID: 31481792
Mitsiadis TA, Magloire H, Pagella P. (2017) Nerve growth factor signalling in pathology and regeneration of human teeth.
Sci Rep. 2017 May 2;7(1):1327. doi: 10.1038/s41598-017-01455-3. PMID: 28465581
Cantù C, Pagella P, Shajiei TD, Zimmerli D, Valenta T, Hausmann G, Basler K, Mitsiadis TA (2017) A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
Sci Signal. 2017 Feb 7;10(465):eaah4598. doi: 10.1126/scisignal.aah4598. PMID: 28174279
